Imiphumela yocwaningo ibonise ukuthi amadoda athola imijovo ye-testosterone undecanoate esebenza isikhathi eside ayenamathela kakhulu ekwelashweni ngemva konyaka ongu-1 kunamadoda athola imijovo ye-testosterone propionate esebenza isikhathi esifushane.
Ukuhlaziywa okubuyiswayo kwedatha evela emadodeni angaphezu kwe-122,000 e-United States kubonise ukuthi amadoda aphathwa nge-testosterone undecanoate (Aveed, Endo Pharmaceuticals) ayenamazinga afanayo okubambelela ezinyangeni zokuqala ze-6 zokwelashwa njengoba amadoda ephathwa nge-testosterone cypionate.Amazinga okubambelela ayesukela ezinyangeni eziyisi-7 kuye kweziyi-12, kanti u-8.2% kuphela weziguli ezelashwe nge-testosterone cypionate eziqhubeka nokwelashwa izinyanga eziyi-12 uma kuqhathaniswa nama-41.9% eziguli ezelashwa nge-testosterone undecanoate.
"Ubufakazi bubonisa ukuthi izindlela ezilula kakhulu zokwelashwa kwe-testosterone, njengomjovo osebenza isikhathi eside, zibalulekile ekuzimiseleni kwamadoda anesifo sokuntuleka kwe-testosterone ukuqhubeka nokwelashwa," kusho u-Abraham Morgenthaler, MD, uprofesa osizayo wokuhlinzwa.UHelio uthe ubesebenza emnyangweni womchamo eBeth Israel Deaconess Medical Center eHarvard Medical School.“Kunokuqashelwa okukhulayo kokuthi ukuntuleka kwe-testosterone kuyisimo sezempilo esibalulekile nokuthi ukwelashwa kwe-testosterone akukwazi ukuthuthukisa izimpawu kuphela kodwa futhi nezinzuzo zezempilo jikelele ezifana nokulawulwa okuthuthukisiwe koshukela egazini, ukunciphisa isisindo samafutha kanye nokwanda kwemisipha, imizwa, ukuminyana kwamathambo kanye nembangela engashiwongo. .i-anemia.Nokho, lezi zinzuzo zingatholakala kuphela uma amadoda enamathela ekwelashweni.”
U-Morgenthaler kanye nozakwabo benza ucwaningo lwe-retrospective cohort lwedatha evela ku-database ye-Verdigm, equkethe idatha yerekhodi yezempilo ye-elekthronikhi evela ezikhungweni zase-US ezilaliswa ngaphandle, okuhlanganisa nalabo abaqala i-testosterone undecanoate ejovayo noma i-testosterone cypionate phakathi kuka-2014 no-2018. Amadoda aneminyaka engu-18 nangaphezulu.Idatha eqoqwe ekunyukeni kwezinyanga eziyi-6 kusukela ngoJulayi 2019. Ukwelashwa kwesondlo kwachazwa njengesikhawu phakathi kwama-aphoyintimenti esingeqi kabili isikhawu somthamo esinconyiwe samaviki angu-20 we-testosterone undecanoate noma amaviki angu-4 e-testosterone cypionate.Ukubambelela ekwelashweni kwahlolwa kusukela ngosuku lomjovo wokuqala kuze kube usuku lokuyekwa, ukuguqulwa kwencwadi kadokotela, noma ukuphela kokwelashwa kwe-testosterone okwakunqunywe ekuqaleni.Ukungabambeleli kwe-Testosterone eqenjini le-testosterone undecanoate kwachazwa njengegebe elingaphezu kwezinsuku ezingu-42 phakathi kosuku lokugcina lokuqokwa kokuqala kanye nosuku lokuqala lokuqokwa kwesibili, noma igebe elingaphezu kwezinsuku ezingu-105 phakathi kokuqokwa kwesikhathi esizayo.Ukungabambeleli eqenjini le-testosterone cypionate kwachazwa njengesikhawu esingaphezu kwezinsuku ezingama-21 phakathi kokuphela kwesikhathi esisodwa kanye nokuqala kokulandelayo.Abaphenyi bahlola izinguquko zesisindo somzimba, i-BMI, umfutho wegazi, amazinga e-testosterone, amazinga ezenzakalo ezintsha zenhliziyo, kanye nezici eziyingozi kusukela ezinyangeni ze-3 ngaphambi komjovo wokuqala ezinyangeni ze-12 ngemuva kokuqala kokwelashwa.
Iqembu locwaningo lalinamadoda angu-948 athatha i-testosterone undecanoate kanye namadoda angu-121,852 athatha i-testosterone cypionate.Ekuqaleni, i-18.9% yamadoda eqenjini le-testosterone undecanoate kanye nama-41.2% amadoda eqembu le-testosterone cypionate awazange abe nokuxilongwa kwe-hypogonadism.Kusho i-testosterone yamahhala ekuqaleni yayiphezulu ezigulini ezithatha i-testosterone undecanoate uma kuqhathaniswa nalabo abathatha i-testosterone cypionate (65.2 pg/mL vs 38.8 pg/mL; P <0.001).
Ezinyangeni ezingu-6 zokuqala, amazinga okubambelela ayefana kuwo womabili amaqembu.Esikhathini esiyizinyanga eziyisi-7 kuya kweziyi-12, iqembu le-testosterone undecanoate laba nenani eliphezulu lokubambelela kuneqembu le-testosterone cypionate (82% vs 40.8%; P <0.001).Uma kuqhathaniswa nezinyanga eziyi-12, ingxenye ephezulu yamadoda eqenjini le-testosterone undecanoate yaqhubeka nokwelashwa kwe-testosterone engenalutho (41.9% vs 0.89.9%; P <0.001).Amadoda athatha i-testosterone cypionate.
"Ngokumangalisayo, amaphesenti angu-8.2 kuphela amadoda afaka i-testosterone cypionate aqhubeka nokwelashwa ngemva konyaka ongu-1," kusho uMorgenthaler.“Inani eliphansi kakhulu lokwelashwa kwe-testosterone esetshenziswa kakhulu e-United States lisho ukuthi amadoda aswele i-testosterone awaphathwa kahle.”
Iziguli ezelashwa nge-testosterone undecanoate zibe nezinguquko ezinkulu zenani ku-testosterone isiyonke (171.7 ng/dl vs 59.6 ng/dl; P <0.001) kanye ne-testosterone yamahhala (25.4 pg/ml vs 3.7 pg/ml; P = 0.001).Ukwanda kwezinyanga ze-12 uma kuqhathaniswa neziguli eziphathwa nge-testosterone cypionate.I-Testosterone undecanoate ibonise ukuhlukahluka okuncane kumazinga e-testosterone ephelele kune-testosterone cypionate.
Ezinyangeni ze-12, ushintsho olusho ngesisindo, i-BMI, nomfutho wegazi kwakufana phakathi kwamaqembu.Iqembu le-testosterone undecanoate lalinenani eliphakeme lamadoda ane-erectile dysfunction esanda kutholakala kanye nokukhuluphala ekulandeleni, kuyilapho iqembu le-testosterone cypionate linenani eliphakeme lamadoda atholakala enesifo somfutho wegazi ophezulu, ukwehluleka kwenhliziyo, nobuhlungu obungapheli.
Kudingeka ucwaningo olwengeziwe ukuze kuqondwe ukuthi kungani amadoda amaningi ajova i-testosterone cypionate eyeka ukwelashwa kungakapheli unyaka, kusho uMorgenthaler.
“Singacabanga ukuthi kulolu cwaningo, i-testosterone undecanoate isetshenziswe ngamanani aphezulu kakhulu izinyanga ze-12 ngenxa yokunethezeka komuthi osebenza isikhathi eside, kodwa ukuze sibone ukuthi lokhu kungenzeka yini ngenxa yezinye izici (njengezindleko), ukwenyanya ukuzijova njalo, ukuntuleka kokuthuthuka okuphawulekayo kwezimpawu, noma ezinye izizathu,” kusho uMorgenthaler.
Isikhathi sokuthumela: Jul-05-2023