Ucwaningo lwakamuva luveze ukuthi amadoda athola imijovo ye-testosterone undecanoate esebenza isikhathi eside kungenzeka ukuthi abambelele ekwelashweni kwawo uma kuqhathaniswa nalabo abathola imijovo ye-testosterone propionate esebenza isikhathi esifushane.Okutholakele kuqokomisa ukubaluleka kwezinhlobo ezilula zokwelashwa kwe-testosterone ekuqinisekiseni ukuzibophezela kwesiguli ekwelashweni.
Lolu cwaningo, olubandakanya ukuhlaziywa kwedatha evela kwabesilisa abangaphezu kwe-122,000 e-United States, kuqhathanise amazinga okubambelela amadoda aphathwa nge-testosterone undecanoate nalawo aphathwa nge-testosterone cypionate.Imiphumela yabonisa ukuthi phakathi nezinyanga ezingu-6 zokuqala zokwelashwa, womabili amaqembu abe namazinga afanayo okubambelela.Kodwa-ke, njengoba isikhathi sokwelashwa sisuka ezinyangeni eziyisi-7 kuye kweziyi-12, ama-8.2% kuphela eziguli ezithola i-testosterone cypionate eziqhubekile nokwelashwa, uma kuqhathaniswa nenani elibalulekile elingu-41.9% leziguli ezithola i-testosterone undecanoate.
UDkt. Abraham Morgenthaler, umsizi kaprofesa wokuhlinza emnyangweni we-urology we-Beth Israel Deaconess Medical Center e-Harvard Medical School, uzwakalise ukubaluleka kwalokhu okutholakele.Wathi, "Ubufakazi buphakamisa ukuthi izindlela ezilula kakhulu zokwelashwa kwe-testosterone, njengemijovo esebenza isikhathi eside, zibalulekile ekuzimiseleni kwamadoda anesifo sokuntuleka kwe-testosterone ukuqhubeka nokwelashwa."UDkt. Morgenthaler ugcizelele ukuqashelwa okukhulayo kokuntuleka kwe-testosterone njengesimo sezempilo esibalulekile futhi wagqamisa izinzuzo ezibanzi zezempilo ezinganikezwa ukwelashwa kwe-testosterone, okuhlanganisa ukulawulwa okuthuthukisiwe koshukela wegazi, ukuncishiswa kwamafutha, ukwanda kwemisipha, isimo sengqondo esithuthukisiwe, ukuminyana kwamathambo, ngisho nokunciphisa. i-anemia.Nokho, ukuqaphela lezi zinzuzo kuncike ekugcineni ukubambelela ekwelashweni.
Ucwaningo, olwenziwa uDkt. Morgenthaler nozakwabo, lwasebenzisa idatha evela kusizindalwazi se-Verdigm, esiqoqa idatha yamarekhodi ezempilo e-elekthronikhi ezikhungweni zokulaliswa ngaphandle kulo lonke elase-United States.Abacwaningi bagxile emadodeni aneminyaka engu-18 nangaphezulu abaqalise ukwelashwa okujovwayo kwe-testosterone undecanoate noma i-testosterone cypionate phakathi kuka-2014 no-2018. Idatha, eqoqwe ngezikhathi zezinyanga eziyisi-6 kuze kube nguJulayi 2019, ivumele abacwaningi ukuthi bahlole ukubambelela ekwelashweni ngokusekelwe esikhathini ama-aphoyintimenti kanye nanoma yikuphi ukuhoxiswa, izinguquko zemithi kadokotela, noma ukuqedwa kokwelashwa kwe-testosterone ebekwe ekuqaleni.
Ngokukhethekile, ukubambelela ekwelashweni kweqembu le-testosterone undecanoate kwachazwa njengegebe elingaphezu kwezinsuku ezingama-42 phakathi kosuku lokugcina lokuqokwa kokuqala kanye nosuku lokuqala lokuqokwa kwesibili, noma igebe elingaphezu kwezinsuku eziyi-105 phakathi kokuqokwa okulandelayo.Eqenjini le-testosterone cypionate, ukungabambeleli kuchazwe njengesikhawu esingaphezu kwezinsuku ezingama-21 phakathi kokuqokwa.Ngaphezu kwamazinga okubambelela, abaphenyi bahlaziye izici ezihlukahlukene ezifana nezinguquko zesisindo somzimba, i-BMI, umfutho wegazi, amazinga e-testosterone, amazinga ezenzakalo ezintsha zenhliziyo nemithambo yegazi, kanye nezici eziyingozi ezifanele kusukela ezinyangeni ze-3 ngaphambi komjovo wokuqala kuya ezinyangeni ezingu-12 ngemva kokuqala kokwelashwa. ukwelashwa.
Lokhu okutholakele kusikhanyisela ngokubaluleka kwemijovo ye-testosterone esebenza isikhathi eside ekukhuthazeni ukubambelela ekwelashweni nasekukhuliseni izinzuzo ezingaba khona zokwelashwa kwe-testosterone.Amadoda anokuntuleka kwe-testosterone angazuza kakhulu ezinhlotsheni ezikahle zokwelapha, ukuqinisekisa ukuqhubeka nokukhuthaza ukuzibophezela kwesikhathi eside ekuthuthukiseni impilo yabo kanye nokuphila kahle.
Isikhathi sokuthumela: Jul-07-2023