Entuthukweni ebalulekile yokunakekelwa kwezempilo, ukwethulwa komuthi wekhwalithi ephezulu obizwa nge-Raloxifene Hydrochloride bekulokhu kushintsha indawo yezinketho zokwelapha.Le mithi emisha ithola ukuqashelwa ngokushesha ngenxa yamandla ayo amangalisayo ekubhekaneni nezimo ezihlukahlukene zempilo kanye nokwenza ngcono izinga lempilo.
I-Raloxifene Hydrochloride, i-oral selective estrogen receptor modulator (SERM), inqunywe ngokuyinhloko ekwelapheni nasekuvimbeleni i-osteoporosis kwabesifazane be-postmenopausal.Lesi simo, esibonakala ngokuncipha kwamathambo, singabangela ingozi eyengeziwe yokuphuka, ikakhulukazi kwabesifazane asebekhulile.I-Raloxifene Hydrochloride ibonakale iphumelela kakhulu ekwehliseni ukulahleka kwamathambo nasekuthuthukiseni ukuminyana kwamaminerali amathambo, ngaleyo ndlela yehlisa ingozi yokuphuka.
Kodwa-ke, izinzuzo ze-Raloxifene Hydrochloride zidlulela ngale kokwelashwa kwe-osteoporosis.Ucwaningo lwakamuva luphinde lwagqamisa amandla alo ekuvimbeleni umdlavuza webele ohlaselayo kwabesifazane abangemva kokuya esikhathini abane-osteoporosis, kanye nokunciphisa ingozi yokuba nomdlavuza webele we-estrogen receptor-positive.Lokhu kutholakala okuyisisekelo kunikeze ithemba elisha kuzo zombili iziguli kanye nabasebenzi bezempilo ekulweni nomdlavuza webele, kuqinisekisa kabusha ukubaluleka kwemithi esezingeni eliphezulu ekuguquleni ukunakekelwa kwezempilo.
Indlela eyingqayizivele ye-Raloxifene Hydrochloride inikeza izinzuzo ezengeziwe ezigulini.Ngokungafani nemithi yokwelapha yokubuyisela amahomoni evamile, ayinayo imiphumela emibi ehlobene ne-estrogen, okuyenza ibe enye indlela engase ibe ephephile.Ukwengeza, i-Raloxifene Hydrochloride ibonise isithembiso ekwelapheni ezinye izimo ezifana ne-endometrial hyperplasia, isandulela somdlavuza we-endometrial, kanye nokunciphisa ingozi yezenzakalo zenhliziyo kwabesifazane be-postmenopausal.
Ukukhiqizwa kwe-Raloxifene Hydrochloride kubambelela ezinyathelweni eziqinile zokulawula ikhwalithi ukuze kuqinisekiswe ukuphepha nokusebenza kwayo.Izinkampani ezenza imithi zitshala izinsiza ezibalulekile ocwaningweni nasekuthuthukisweni, zisebenzisa ubuchwepheshe obusezingeni eliphezulu kanye nemithethonqubo yokuhlola eqinile ukuze kuqinisekiswe amazinga aphezulu kakhulu.Lokhu kuzibophezela kwikhwalithi kubalulekile ekuhlinzekeni ngemithi esebenzayo iziguli ezingayethemba, ekugcineni kube ngcono imiphumela yezempilo.
Ngaphezu kwalokho, ukufinyeleleka emithini yekhwalithi ephezulu njenge-Raloxifene Hydrochloride kubalulekile ekuthuthukisweni kokunakekelwa kwezempilo kukonke.Ngokubeka phambili ukufinyelela okuthengekayo nokulinganayo, ohulumeni, abahlinzeki bezokunakekelwa kwempilo, nezinkampani ezenza imithi zingasebenzisana ukuze kuqinisekiswe ukuthi iziguli ezidinga usizo zingathola lo muthi woguquko ngaphandle komthwalo wezezimali ongadingekile.
Ngenxa yezinzuzo eziningi ezinikezwa yi-Raloxifene Hydrochloride, ochwepheshe bezokunakekelwa kwempilo kanye neziguli ngokufanayo bayanxuswa ukuthi bahlale benolwazi ngalo muthi oyisisekelo.Ukubonisana nabahlinzeki bezempilo kubalulekile ekuhloleni ukusetshenziswa okungenzeka kwe-Raloxifene Hydrochloride ngale kokwelashwa kwe-osteoporosis nokuqonda ukufaneleka kwayo ezimweni ngazinye.
Ucwaningo oluqhubekayo nokuhlolwa komtholampilo kwenziwa ukuze kuhlolwe amandla aphelele e-Raloxifene Hydrochloride ezimweni ezihlukahlukene zezempilo.Umphakathi wezokwelapha usalokhu unethemba mayelana namathuba esikhathi esizayo alo muthi wekhwalithi ephezulu, uvula indlela yemiphumela yezempilo ethuthukisiwe kanye nokwenza ngcono izinga lempilo jikelele leziguli.
Sengiphetha, ukwethulwa komuthi wekhwalithi ephezulu i-Raloxifene Hydrochloride kube nomthelela omkhulu ekunakekelweni kwezempilo.Ngokusebenza kwayo ngempumelelo ekwelapheni i-osteoporosis kanye nezicelo ezingase zibe khona ekuvimbeleni umdlavuza webele, i-endometrial hyperplasia, nempilo yenhliziyo nemithambo yegazi, i-Raloxifene Hydrochloride imele impumelelo kwisayensi yezokwelapha.Njengoba ukufinyeleleka nokuqwashisa kwalo muthi kukhula, unamandla okuguqula izinqubo zokunakekelwa kwezempilo futhi uthuthukise inhlalakahle yeziguli emhlabeni wonke.
Isikhathi sokuthumela: Jul-07-2023